ABSTRACT
Objectives Severe acute respiratory syndrome coronavirus 2 has infected millions of people worldwide with extensive affection and damage to body systems and organs;hence, the study of post-coronavirus disease (COVID) sequences is mandatory. Till now, reports are upcoming on the considerable effects of COVID-19 on male sexual health with no final data. Patients and Methods: Our cohort study included 76 male COVID-19-infected patients, confirmed positive via nasopharyngeal PCR swab. The rationale of this study was to estimate the influence of clinical, laboratory, and radiological severity parameters of COVID-19 on male erectile dysfunction based on erectile scores and male sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol). Result(s): Our results have demonstrated a highly statistically significant correlation between COVID-19 severity (mild, moderate, and severe cases) and both erectile scores (erection hardness score and International Index of Erectile Dysfunction-5) and testosterone hormones at first and third month after COVID (P0.001), except for testosterone level at third month and COVID-19 severity, which showed a statistically significant difference, with P value of 0.031. Conclusion(s): The current study correlated the effect of COVID-19 severity in the terms of clinical, laboratory, and radiological presentations on male sexual dysfunction (erectile scores and testosterone hormone) at first and third month after hospital discharge, with statistical significance being highly affected in severe rather than moderate and mild cases. This strengthens the obvious effect of COVID-19 infection on male sexual dysfunction. Copyright © 2023 The Egyptian Journal of Chest Diseases and Tuberculosis.
ABSTRACT
Objectives The corona virus SARS-COV-2 has affected millions of people all over the world with much affection and damage to body systems and organs, and still, its long-term effects are debatable. Up till now, a lot of ongoing researches are being conducted to evaluate the deleterious effect of coronavirus disease 2019 (COVID-19) on various systems, including reproduction, however, it is still debatable. Patients and methods Our cohort study included a total of 57 male COVID-19 patients, confirmed positive via nasopharyngeal PCR swab. The aim of the study was to evaluate the correlation between the severity of COVID-19 infection and post-COVID sequelae on male-reproductive functions as regards semen parameters and male-hormone profile at the first and third month after discharge from the hospital. Results Our results have demonstrated highly statistically significant changes in sperm concentration, sperm total, and progressive motility, as well as follicle-stimulating hormone, luteinizing hormone, and E2-hormone levels on the first and third month post-COVID infection with P value less than 0.001. In the same context, there was a statistical significance to testosterone-hormone level with P value 0.003. According to COVID-19 severity, there was a highly significant correlation between the degree of severity and affection of sperm concentration, total, and progressive motility with P value less than 0.001. In contrast, there was no significant correlation between the severity of infection and male-hormone profile. Conclusion The current study revealed a negative influence of COVID-19 infection on semen parameters as well as male-sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and E2) on the first and third month post-COVID infection;however, only semen parameters were affected by the degree of disease severity. Copyright © 2022 The Egyptian Journal of Chest Diseases and Tuberculosis.
ABSTRACT
Background: There is solid evidence that olfactory dysfunction (OD) can present in COVID-19 patients. Anosmia can be the only presentation or can be accompanied by other symptoms of COVID-19. Multiple cross-sectional studies have demonstrated that the incidence rate of olfactory dysfunction is high in COVID-19 patients with good prognosis. The aim of our study is to investigate the presence of OD with the radiologic and laboratory findings among COVID-19 positive patients. Results: There was statistical significance in clinical severity between anosmia and non-anosmia group (P value 0.000) denoting that anosmia sign mostly occur in mild COVID. Also, there was significance in D dimer between two groups (P value 0.044) denoting that D dimer could be a sign of clinical severity and it is usually not elevated in anosmia. All anosmia group had normal CT chest denoting that it is a mild form of COVID-19. Conclusions: Olfactory dysfunction (OD) is an imminent sign of COVID-19 patient, which can be presented as a sole symptom or with other symptoms. As anosmia could be the sole clinical presentation of COVID-19 patients without any other significant signs and so otolaryngologists should be aware of this presentation in COVID-19 diagnosis. © 2021, The Author(s).
ABSTRACT
Objective In the past few months, WHO declared coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 as a major pandemic, with increasing number of discovered cases and mortalities in all countries. Up till now, there are a lot of controversial data on its pathogenesis, possible complications, prognostic factors, and available preventive and/or therapeutic options. A series of fast growing research studies are being conducted aiming at studying prognostic criteria that may predict the disease severity and possible outcomes and hence plan of management either home or hospital management. Patients and methods Our cohort study included 73 COVID-19-confirmed positive cases by nasopharyngeal swab/reverse transcriptase PCR to evaluate correlation between serum ferritin levels (baseline and follow-up samples at day 7), as well as C-reactive protein levels and severity of clinical presentation of COVID-19-infected patients. Results Our results have demonstrated a statistically significant difference between mild (n=40) and moderate cases (n=33) regarding baseline ferritin level (P=0.00);however;no significant difference was detected among ferritin changes during the course of the disease (P=0.744), and also, no statistically significant difference in ferritin changes was found among mild and moderate severity groups (P=0.942). Finally, the only significant predictors of clinical severity were baseline ferritin and C-reactive protein levels according to multivariate analysis model (P=0.014 and =0.000, respectively). Conclusions The current study added further evidence to suggest baseline serum ferritin as an index of severity in COVID-19 and could have a prognostic effect;however, we cannot rely on follow-up serum ferritin during treatment and the course of the disease to predict outcome of the disease, and it may be misleading.